王征实验室重点关注融合磁共振影像学、认知决策计算、行为学、转录组学及神经调控技术，探索精神疾病的量化诊断与个体化干预。研究特色在于构建非人灵长类疾病模型，解析临床情感认知障碍类疾病的环路机制，研创神经调控新技术开展认知干预治疗，开辟灵长类动物模型向临床转化应用的新途径，推进精神疾病的客观诊疗。相关研究成果以资深或通讯作者身份发表在Science（2017）、Neuron(2013且同期配发专文点评、2018、2020、2022)、Nat Commun(2023)、Cell Discovery(2021)、Cell Reports(2023)、Am J Psychiatry（2021且同期配发专文点评）、Mol Psychiatry（2022）、J Neurol Neurosurgery Psychiatry (2021)、Biol Psychiatry (2016、2018，两次同期配发专文点评)、eLife（2022）、J Neurosci (2016、2020)、Cereb Cortex (2018、2021)、EBioMedicine(2017、2022)、IEEE TMI（2015）等国际主流学术期刊上。

目前聚焦的研究方向包括：

开展超高场灵长类磁共振成像与转录组学大数据研究，挖掘脑联接图谱的生物学基础；

重点解析强迫症、物质成瘾等情感认知障碍类疾病的环路机制，建立影像学指标评估优化认知行为、药物以及深部脑刺激等治疗方案的临床疗效；

利用基因编辑等多种技术手段建立灵长类动物疾病模型，同时并行开展临床研究（包括转录组学、行为学、影像学和神经调控干预），探索模式动物-人类临床试验相互的转化路径，发展跨物种智能算法辅助的精准诊断和治疗。

代表性论著

Lv Q¹, Zhang M¹, Jiang HF¹, Liu YL, Zhao SL, Xu XM, Zhang WL, Chen TZ, Su H, Zhang JT, Wang HQ, Zhang JM, Feng YJ, Li YQ, Li B*, Zhao M*, Wang Z*, Metabolic and functional substrates of impulsive decision bias in abstinent heroin addicts after prolonged methadone maintenance treatment, NeuroImage, 2023, 283:120421. 

Wang W¹, Bo TT¹, Zhang G1, Li J, Ma JJ, Ma LX, Hu GL, Tong HG, Lv Q, Daniel JA, Luo D, Chen YJ, Wang MY, Wang Z*, Wang G.-Z.*, Noncoding transcripts are linked to brain resting-state activity in non-human primates, Cell Reports, 2023, 42: 112652.

Lv Q*, Zeljic K, Zhao SL, Zhang JT, Zhang JM, Wang Z*, Dissecting psychiatric heterogeneity and comorbidity with core region-based machine learning, Neuroscience Bulletin, 2023, https://doi.org/10.1007/s12264-023-01057-2 . (Invited Review)

Bo TT¹, Li J¹, Hu GL, Zhang G, Wang W, Lv Q, Zhao SL, Qin M, Yao XH, Wang MY*, Wang GZ*, Wang Z*., Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys, Nature Communications, 2023, 14：1499-1514.

Yan MC¹, Yu WW¹, Lv Q, Lv QM, Bo TT, Chen XY, Liu YL, Zhan YF, Yan SY, Shen XY, Yang BF, Hu QM, Yu JL, Qiu ZL, Feng YJ, Zhang XY, Wang H, Xu FQ, Wang Z*, Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography, Elife, 2022, 11: e72534.

Chen XY¹, Wang Z¹, Lv Q, Lv QM, van Wingen G, Fridgeirsson EA, Denys D, Voon V, Wang Z*, Common and differential connectivity profiles of deep brain stimulation and capsulotomy in refractory obsessive-compulsive disorder, Molecular Psychiatry, 2022, 27(2):1020-1030.  

Qin DD¹, Zhou JK¹, He XC¹, Shen XY¹, Li C, Chen HZ, Yan LZ, Hu ZF, Li X, Lv LB, Yao YG*, Wang Z.*, Huang XX*, Hu XT*, Zheng P*, Depletion of giant ANK2 in monkeys causes drastic brain volume loss, Cell Discovery, 2021, 7(1):113. 

Zhang CC¹, Kim S-G¹, Li J, Zhang YY, Lv QM, Zeljic K, Gong HF, Wei HG, Liu WJ, Sun BM, Wang Z*, Voon V*., Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder, Journal of Neurology, Neurosurgery, and Psychiatry, 2021, 92(6): 637-644.

Lv Q¹, Lv QM¹, Yin DZ, Zhang CC, Sun BM, Voon V*, Wang Z*, Neuroanatomical substrates and predictors of response to capsulotomy in intractable obsessive-compulsive disorder, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2021, 6(1):29-38. 

Zhan YF¹, Wei JZ¹, Liang J, Xu X, He R*, Robbins TW, Wang Z.*, Diagnostic classification for human autism and obsessive-compulsive disorder based on machine learning from a primate genetic model, American Journal of Psychiatry, 2021, 178(1): 65-76. [Commentary by van den Heuvel OA, Can Transgenic monkeys help us innovate transdiagnostic therapies?  American Journal of Psychiatry, 2021, 178(1): 8-10.]

Lv QM, Yan MC, Shen XY, Wu J, Yu WW, Yan SY, Yang F, Zeljic K, Shi YQ, Zhou ZF, Lv LB, Hu XT, Menon R, Wang Z.*, Normative analysis of individual brain differences based on a population MRI-based atlas of cynomolgus macaques, Cerebral Cortex, 2021, 31(1): 341-355.

Cai DC¹, Wang ZW¹, Bo TT¹, Yan SY¹, Liu YL, Liu ZW, Zeljic K, Chen XY, Zhan YF, Xu X, Du YS, Wang YW, Cang J, Wang GZ, Zhang J, Sun Q, Qiu ZL, Ge SJ*, Ye Z, Wang Z.*, MECP2 duplication causes aberrant GABA pathways, circuits and behaviors in transgenic monkeys: neural mappings to patients with autism, Journal of Neuroscience, 2020, 40(19): 3799-3814.

Cui YN, Li X, Zeljic K, Shan SF, Qiu ZL*, Wang Z*, Effect of PEGylated magnetic PLGA-PEI nanoparticles on primary hippocampal neurons: reduced nano-neurotoxicity and enhanced transfection efficiency with magnetofection, ACS Applied Materials & Interfaces, 2019, 11(41): 38190-38204.

Chen XY¹, Zhang CC¹, Li YX¹, Lv Q, Zeljic K, Huang P, Jin HY, Chen SD, Sun BM*, Wang Z.*, Functional connectivity-based modelling simulates subject-specific network effects of focal brain stimulation, Neuroscience Bulletin, 2018, 34(6):921-938.

Yin DZ¹, Zhang CC¹, Lv QM, Chen XY, Zeljic K, Gong HF, Zhan SK, Jin HY, Wang Z.*, Sun BM*, Dissociable frontostriatal connectivity: mechanism and predictor of the clinical efficacy of capsulotomy in obsessive-compulsive disorder, Biological Psychiatry, 2018, 84(12): 926-936. [Commentary by Hoexter MQ, Are we ready for individualized target planning of ablative procedures in intractable obsessive-compulsive disorder? Biological Psychiatry, 2018, 84(12): e85-e87]

Lv QM¹, Wang Z¹, Zhang CC¹, Fan Q, Zeljic K, Sun BM, Xiao ZP*, Wang Z.*, Divergent structural responses to pharmacological interventions in orbitofronto-striato-thalamic and premotor circuits in obsessive-compulsive disorder, EBioMedicine, 2017, 22:242-248.

Zhou TT¹, Zhu H¹, Fan ZX, Wang F, Chen Y, Liang HX, Yang ZF, Zhang L, Lin LN, Zhan Y, Wang Z, Hu H*, History of winning remodels thalamo-PFC circuit to reinforce social dominance, Science, 2017, 357: 162-168.

Yin DZ, Liu WJ, Zeljic K, Wang ZW, Lv Q, Fan MX, Cheng WH*, Wang Z*, Dissociable changes of frontal and parietal cortices in inherent functional flexibility across the human lifespan, Journal of Neuroscience, 2016, 36(39):10060-10074.

Lv Q¹, Yang LQ¹, Li GL, Wang ZW, Shen ZM, Yu WW, Jiang QY, Hou BY, Pu J, Hu H*, Wang Z.*, Large-scale persistent network reconfiguration induced by ketamine in anesthetized macaques: relevance to mood disorders, Biological Psychiatry, 2016, 79: 765-775. [Commentary by Arnsten AF, Murray JD, Seo H, and Lee D. Ketamine’s antidepressant actions: potential mechanisms in the primate medial prefrontal circuits that represent aversive experience, Biological Psychiatry, 2016, 79: 713-715]

Pu J, Wang J, Yu WW, Shen ZM, Lv Q, Zeljic K, Zhang CC, Sun BM, Liu GX, Wang Z.*. Discriminative structured feature engineering for macroscale brain connectomes, IEEE Trans Med Imaging, 2015, 34(11):2333-2342.

Wang Z¹., Chen LM¹, Negyessy L¹, Friedman RM, Mishra A, Gore JC*, Roe AW*, The relationship of anatomical and functional connectivity to resting state connectivity in primate somatosensory cortex, Neuron, 2013, 78:1116-1126. [Previews by Olaf Sporns and Christopher J Honey, “Topographic dynamics in the resting brain”, 78, 955-956] 

其它论著

Liu CC, Li KS, Zheng XX, Fu MN, Zhang YY, Sindermann C, Montag C, Wang Z, Zhou B, Kendrick K, Becker B, A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men, European Neuropsychopharmacology, 2023, 77: 24-34.

Liu WH¹, Xie H¹, Liu X¹, Xu SJ, Cheng SS, Wang Z, Xie T, Zhang Z-C*, Han JH*, PQBP1 regulates striatum development through balancing striatal progenitor proliferation and differentiation, Cell Reports, 2023, 42：112277.

Zhang M¹, Qin QK¹, Zhang SN, Liu W, Meng HP, Xu MY, Huang XY, Lin XZ, Lin M, Herman P, Hyder F, Stevens RC, Wang Z, Li B*, Thompson GJ*, Aerobic glycolysis imaging of epileptic foci during the inter-ictal period, EBioMedicine, 2022, 79:104004.  

Li G, Huang P*, Cui SS, Tan YY, He YC, Shen X, Jiang QY, Huang P, He GY, Li BY, Li YX, Xu J, Wang Z*, Chen SD*, Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson’s disease patients, Translational Neurodegeneration, 2022, 11: 6-16.

The PRIMatE Data and Resource Exchange (PRIME-DRE) Global Collaboration Workshop and Consortium, Toward next-generation primate neuroscience: a collaboration-based strategic plan for integrative neuroimaging, Neuron, 2022, 110: 1-5.

Hong J¹, Bo TT¹, Xi LQ¹, Xu XQ¹, He NY¹, Zhan YF, Li WY, Liang PW, Chen YF, Shi J, Yan FH, Gu WQ, Wang WQ, Liu RX, Wang JQ*, Wang Z*, Ning G, Reversal of functional brain connectivity associated with gut microbiome and gastrointestinal hormones after vertical sleeve gastrectomy in obese patients, Journal of Clinical Endocrinology & Metabolism, 2021, 106(9): e3619-e3633.

Wang Y, Lu PW, Zhan YF, Wu XW, Qiu YG, Wang Z, Xu Q, Zhou Y, The contribution of white matter diffusion and cortical perfusion pathology to vascular cognitive impairment: a multimode imaging-based machine learning study, Frontier in Aging Neuroscience, 2021, 13:687001.

Wang XD, Li XH, Cho JW, Russ B, Rajamani N, Omelchenko A, Ai L, Korchmaros A, Sawiak S, Benn A.R., Garcia-Saldivar P, Wang Z, Kalin NH, Schroeder CE, Craddock RC, Fox AS, Evans AC, Messinger A, Milham MP, Xu T*, U-Net model for brain extraction: trained on humans for transfer to non-human primates, NeuroImage, 2021, 235:118001.

Feng L¹, Yin DZ¹, Wang XB, Xu YF, Xiang YS, Teng F, Pan YG, Zhang XL, Su JH, Wang Z*, Jin LJ*, Brain connectivity abnormalities and treatment-induced restorations in patients with cervical dystonia, European Journal of Neurology, 2021, 28(5):1537-1547.

Zeljic K¹, Xiang Q¹, Wang ZW, Pan YY, Shi YQ, Zhou ZF, Wang Z*, Liu DT*, Heightened perception of illusory motion is associated with symptom severity in Schizophrenia patients, Progress in Neuropsychopharmacology & Biological Psychiatry, 2021, 104:110055.

Tong QQ, Gong T, Wang Z, Yu WW, Zhang JJ, Zhai LH, Cui HS, Meng X, Tax CT, Zhong JH, He HJ, A deep learning–based method for improving reliability of multicenter diffusion kurtosis imaging with varied acquisition protocols, Magnetic Resonance Imaging, 2020, 73:31-44.

Pu R, Wu Z, Yu WW, He HJ*, Zhou ZF, Wang Z*, Zhong JH, Association of myelination in the internal capsule with iron deposition in the basal ganglia in macaques: a magnetic resonance imaging study, Quantitative Imaging in Medicine and Surgery, 2020, 10(7):1526-1539.  

Su H¹, Liu YL¹, Yin DZ, Chen TZ, Li XT, Zhong N, Jiang HF, Wang JJ, Du J, Xiao K, Xu D, Zeljic K, Wang Z*, Zhao M*, Neuroplastic changes in resting-state functional connectivity after rTMS intervention for methamphetamine craving, Neuropharmacology, 2020, 175: 108177

Su H¹, Chen TZ¹, Zhong N, Jiang HF, Du J, Xiao K, Xu D, Wang Z, Zhao M*, GABA and Glutamate/glutamine alterations of the left prefrontal cortex in individuals with methamphetamine use disorder: a combined TMS-MRS study, Annals of Translational Medicine, 2020, 8(6): 347-356.

The PRIMatE Data Exchange (PRIME-DE) Global Collaboration Workshop and Consortium, Accelerating the evolution of nonhuman primate neuroimaging, Neuron, 2020, 105: 600-602

Yin DZ, Chen XY, Zeljic K, Zhan YF, Shen XY, Yan G, Wang Z*, Topological architecture of functional diversity of brain regions and its association with human intelligence, Brain and Behavior, 2019, 9:e01358.

Zhang Z¹, Cai DC¹, Wang ZW, Zeljic K, Wang Z*, Wang YW*, Isoflurane-induced burst suppression increases intrinsic functional connectivity of the monkey brain, Frontiers in Neuroscience, 2019, 13: 296. doi: 10.3389/fnins.2019.00296.

Fang F, Lai MY, Huang JJ, Kang M, Ma MM, Li KA, Lian JG, Wang Z, Yin DZ*, Wang YF*, Compensatory hippocampal connectivity in young adults with early-stage type 2 diabetes, Journal of Clinical Endocrinology & Metabolism, 2019, 104(7): 3025-3038.

Xiang Q, Xu JL, Wang YC, Chen TY, Wang JH, Zhuo KM, Guo XY, Zeljic K, Li WL, Sun Y, Wang Z, Li Y*, Liu DT*, Modular functional-metabolic coupling alterations of frontoparietal network in Schizophrenia patients, Frontiers in Neuroscience, 2019, 13:40. doi: 10.3389/fnins.2019.00040.

Yin DZ, Zhang Z, Wang ZW, Zeljic K, Lv Q, Cai DC, Wang YW, Wang Z.*, Brain map of intrinsic functional flexibility in anesthetized monkeys and awake humans, Frontiers in Neuroscience, 2019, 13:174. doi: 10.3389/fnins.2019.00174.

Li HF¹, Yang LQ¹, Yin DZ¹, Chen WJ, Liu GL, Ni W, Wang N, Yu WW, Wu ZY*, Wang Z.*, Associations between neuroanatomical abnormalities and motor symptoms in paroxysmal kinesigenic dyskinesia, Parkinsonism & Related Disorders, 2019, 62:134-140.

Milham MP, Ai L, Koo B, Xu T, Amiez C, Balezeau F, Baxter MG, Blezer ELA, Brochier T, Chen AH, Croxson PL, Damatac CG, Dehaene S, Everling S, Fair D, Fleysher L, Freiwald W, Froudist-Walsh S, Griffiths TD, Guedj C, Hadj-Bouziane F, Hamed SB, Harel N, Hiba B, Jarraya B, Jung B, Kastner S, Klink PC, Kwok SC, Laland K.N., Leopold DA, Lindenfors P, Mars RB, Menon RS, Messinger A, Meunier M, Mok K, Morrison JH, Nacef J, Nagy J, Rios MO, Petkov CI, Pinsk M, Poirier C, Procyk E, Rajimehr R, Reader SM, Roelfsema PR, Rudko D, Rushworth MFS, Russ B, Sallet J, Schmid M, Schwiedrzik CM, Seidlitz J, Sein J, Shmuel A, Sullivan EL, Ungerleider L, Thiele A, Todorov OS, Tsao D, Wang Z, Wilson CRE, Yacoub E, Ye F, Zarco W, Zhou YD, Margulies DS, Schroeder C, An open resource for nonhuman primate imaging, Neuron, 2018, 100:1-14.

Wang ZW, Zeljic K, Jiang QY, Gu Y, Wang W, Wang Z*, Dynamic network communication in the human functional connectome predicts perceptual variability in visual illusion, Cerebral Cortex, 2018, 28(1): 48-62.

Wu XW, Liao XX, Zhan YF, Cheng C, Shen W, Huang MF, Zhou ZF, Wang Z, Qiu ZL, Xing W, Liao WH, Tang BS, Shen L, Microstructural alterations in Asymptomatic and Symptomatic Patients with Spinocerebellar Ataxia Type 3: a TBSS study, Frontiers in Neurology, 2017, 8:714, doi.org/10.3389/fneur.2017.00714

Wen Z, Cheng TL, Yin DZ, Sun SB, Wang Z, Yu SY, Zhang Y, Qiu ZL, Du YS, Identification of the genetic cause for childhood disintegrative disorder by whole-exome sequencing, Neuroscience Bulletin, 2017, 33(2): 251-254.

Xiang Q, Wang Y, Zhang J, li Y, Xiao Z, Jiang K, Xu Y, Fan X*, Wang Z*, Liu D*. Progressive brain changes in the early stage of schizophrenia: a combined structural MRI and DTI study. Neuropsychiatry, 2017, 8(1): 739–44

Yin DZ¹, Liu WJ¹, Wang ZW, Zeljic K, Bo TT, Lv Q, You MN, Men WW, Fan MX, Cheng WH*, Wang Z*., Failure in cognitive suppression of negative affect in adolescents with generalized anxiety disorder, Scientific Reports, 2017, 7:6583, doi:10.1038/s41598-017-07063-5.

Pan YX¹, Wang LJ¹, Wang ZW¹, Xu C, Yu WW, Spillmann L, Gu Y*, Wang Z.*, Wang W*. Representations of illusory and real rotations in human MST– a cortical site for the Pinna illusion, Human Brain Mapping, 2016, 37: 2097-2113. (cover story)

Yu WW, Lv QM, Zhang CC, Shen ZM, Sun BM, Wang Z.*, High-angular diffusion MRI in reward-based psychiatric disorders. Sun BM and De Salles A (Eds.), Neurosurigcal Treatments for Psychiatric Disorders, Chapter 2, pp.21-34, 2014, Springer Netherlands.

Wang Z., Qi H-X, Kaas JH, Roe AW, Chen LM, Functional signature of recovering cortex: dissociation of local field potentials and spiking activity in somatosensory cortices of spinal cord injured monkeys, Experimental Neurology, 2013, 249:132-143.